Overview of Picked Chemical Compounds and Intermediates
Overview of Picked Chemical Compounds and Intermediates
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one. Pharmaceutical Intermediates
Bortezomib Acid Impurity: This can be an impurity relevant to bortezomib, a proteasome inhibitor Utilized in the remedy of several myeloma. Its synthesis or examine is critical for ensuring the purity and protection on the drug.
Abiraterone Acetate Intermediate (CAS NO. 122111-01-seven): A precursor from the synthesis of abiraterone acetate, a drug used in the remedy of prostate cancer by inhibiting androgen production.
Imatinib Intermediate (CAS NO. 152460-ten-1): A key compound during the synthesis of imatinib, a drug that targets distinct kinds of most cancers, which includes Serious myelogenous leukemia (CML).
Docetaxel Intermediate: A compound used in the synthesis of docetaxel, a chemotherapy medication that treats different cancers which include breast, lung, and prostate cancer.
2. Chemical Impurities and Byproducts
GeMcitabine Intermediates (T6, T9, eight): These are generally intermediates in the synthesis of gemcitabine, an anti-cancer drug. Their research is very important for optimizing the output method and guaranteeing substantial purity.
Lapatinib Intermediate (CAS NO. 231278-eighty four-5): Lapatinib is employed to treat breast cancer, and these intermediates are 3 linked to its manufacturing.
Fulvestrant Intermediates: Fulvestrant is definitely an estrogen receptor antagonist Employed in the treatment method of breast most cancers. Different intermediates help in the synthesis of the drug.
Paclitaxel Aspect Chain Acid (CAS NO. 949023-sixteen-nine): This intermediate is Employed in the synthesis of paclitaxel, a chemotherapy drug efficient in dealing with cancers which include ovarian, breast, and lung cancer.
three. Other Noteworthy Compounds
Irinotecan Hydrochloride Trihydrate (CAS NO. 136572-09-3): A chemotherapy drug Employed in the remedy of colorectal cancer and smaller mobile lung most cancers.
3-Amino-1-hydroxyadamantane (CAS 702-82-nine): This compound is linked to the 2'-Difluoro-2'-deoxycytidine-3' synthesis of adamantane derivatives, that have several apps, like antiviral Qualities.
Vildagliptin Intermediates: Utilized in the creation of vildagliptin, an oral drug for style two diabetic issues that inhibits the enzyme DPP-four to manage blood sugar degrees.
four. Miscellaneous Compounds
D-Gluconic Acid δ-Lactone (CAS NO. 61259-forty eight-one): This compound is linked to the synthesis of assorted gluconic acid derivatives, that happen to be Utilized in food items, pharmaceutical, and industrial apps.
Canagliflozin Intermediate 2: A precursor inside the synthesis of canagliflozin, a medication employed to handle kind two diabetic issues by inhibiting sodium-glucose co-transporter 2 (SGLT2).